iRhom2 protein involved in obesity detection
Colin Adrain, who is a principal investigator of the research, says: “During the research, we found that iRhom2 protein is strongly present in metabolic tissues and organs, which made us decide to study the role of iRhom2 in obesity in more detail.”
The study, published in the Molecular Metabolism journal, demonstrates how the researchers reached the results. They used an animal model, comparing groups with iRhom2 deletion to controls, and feeding them with a normal diet versus a high-fat diet.
Marina Badenes, who is the main author of the paper, explained that “the deletion of iRhom2 led to enhanced energy consumption in adipose tissue, which protected animals from fat accumulation and inflammation, fatty liver and insulin resistance when the animals were placed on a diet that predisposed them to obesity.”
However, researchers intend to further explore the mechanisms and types of cells involved in obesity control iRhom2 and to identify the specific targets involved in the protection against obesity-associated with loss of iRhom2.
